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Estrogen comes from the secretion of ovarian follicle cells and so on, mainly estuarial. It Is a wide range of biological activity of a class of steroid compounds. It is not only the promotion and maintenance of female reproductive organs and the physiological role of secondary sexual characteristics, it also has a significant impact on the endocrine system, cardiovascular system, the body's metabolism, growth and maturation of bone, skin and so on.
Estrogen has the following features:
(1)Stimulation of the external female genitalia, vagina, uterus and other organs with the development, maturation, and promotes vaginal epithelial cell differentiation and keratinization; increase the glycogen of epithelial cells, and breakdown glycogen to keep acidic vaginal environment to enhance their antimicrobial capacity.
(2) Enhance contraction between the fallopian tubes and uterine smooth muscle.
(3) Estrogen with progesterone, maintain a normal menstrual cycle.
(4) Stimulate and maintain female secondary sexual characteristics, such as: the fat and hair distribution with female characteristics, breast development, resulting in the areola, wide pelvis and so on.
(5) Role in retaining water and sodium, increase in extracellular fluid; and can promote muscle protein synthesis, enhance calcium calm and so on.
Progesterone secretes by ovarian luteal cells and mainly progesterone (progesterone)-based. Inactivated in the liver became pregnant after diol glucuronide excreted through urine. Estrogen and progesterone effects are often generated on the basis of effectiveness. The main physiological functions: (1) inhibition of ovulation, to promote endometrial hyperplasia, to facilitate the implantation of fertilized eggs, and lower uterine muscle excitability, to ensure the safety of pregnancy.(2) to promote the growth of mammary gland for lactation in preparation.(3) increase body temperature and make blood vessels and gastrointestinal smooth muscle relaxation.(4) as the pregnancy hormone is testosterone, estrogen, adrenal cortex hormones and other important intermediate in the biosynthesis of, so to varying degrees, with the above types of hormones.
Estrogen, progesterone and human health are closely linked. Menopausal syndrome, arteriosclerosis, cerebral vascular obstruction, osteoporosis, Alzheimer’s disease, weary, back pain, sore shoulders, frigidity, irregular menstruation, irregular menstruation, amenorrhea, infertility, breast dysphasia , dry skin, yellowish, rough, loss of elasticity, wrinkles, miasma, etc., all these symptoms lead to lower hormone secretion in vivo and endocrine disorders. But estrogen and progesterone secretion continues to decline with age. And estrogen and progesterone in vitro can not be supplemented through food, that’s because estrogen and progesterone in the human or animal body can only generate by themselves.
The safety of estrogen has been very controversial. Many scientists find that estrogen can increase the incidence of gynecologic cancer. The U.S.government said the FDA announcement; long-term use of estrogen synthesis can improve the incidence of gynecologic cancer by 20%.
Estrogen therapy has been popular at home and abroad, and indeed this approach can fast and effective replacement estrogen, but its side effects are huge. July 9, 2002, U.S.health officials announced they had suspended a large-scale study of menopause hormones for women, because these drugs cause women to cardiovascular disease and increase risk of breast cancer by 29%.This large study of women's health is well-known start-up projects, which cost of $ 725,000,000.
Cytokines can repair women autologous cells, build the female reproductive system. Women can strengthen the balance of secretion from the body of estrogen and progesterone, especially in after menopauses need to induce cytokines in estrogen and progesterone secretion from the body.
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